According to The Hollywood Reporter, the Bride Wars and Letters To Juliet director passed away after suffering from brain cancer.
"He was suffering from brain cancer for quite some time, and it ultimately metastasised throughout his body," explained his manager Rosalie Swedlin.
Swedlin, who said that a memorial service for Winick was being planned, added: "What's remarkable is that after his first surgery, he was able to direct Letters To Juliet. It was a battle that we thought he had won, and ultimately they just didn't get it all."
Winick produced 19 independent films after founding production company InDigEnt in 1999.
His other films as a director include 13 Going on 30, Tadpole and Sweet Nothing.
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